Lymphedema, a swelling in certain areas of the body, usually the arms and legs, occurs from a blockage within the lymphatic system. The lymphatic system helps to fight infection and disease by carrying lymph, a colorless fluid containing white blood cells, through the body. Acute lymphedema, which is often brought about by cancer treatment, usually goes away after six months. Chronic lymphedema, however, has no cure, although there are certain ways to manage it and keep it from getting worse. No matter the type, untreated lymphedema may result in decreased function and mobility in the affected part of the body, and can result in chronic infections and various illnesses.
Lymphedema is divided into two categories, primary and secondary, both of which have a number of causes.
Primary Lymphedema
A rare, inherited condition, primary lymphedema is caused by lymph-vessel-development issues, and occurs most frequently in women. Causes of primary lymphedema often include:
Milroy's disease
Also called congenital lymphedema, Milroy's disease causes lymph nodes to form abnormally. This condition usually begins in childhood.
Meige's disease
Also called lymphedema praecox, Meige's disease causes lymph vessels to form without the valves that prevent the backward flow of lymph fluid. As a result, the body cannot drain lymph fluid from the limbs. Meige's disease usually manifests itself in childhood or puberty, but can occur in those in their early twenties or thirties.
Late-onset lymphedema
Also called lymphedema tarda, late-onset lymphedema occurs rarely and usually manifests itself in those 35 and older.
Secondary Lymphedema
Secondary lymphedema arises from any condition or procedure that damages lymph nodes or lymph vessels. Causes of secondary lymphedema may include:
Surgery
If lymph nodes and lymph vessels are removed or cut during surgery, lymphedema may result. Lymph nodes are often removed in the underarm, groin or pelvic areas to treat breast cancer, gynecologic cancers, prostate cancer, testicular cancer, bladder cancer and melanomas, and lymphedema is often a side effect.
Radiation treatment
Radiation treatment can cause scarring and inflammation to lymph nodes or lymph vessels, which affects the flow of lymph fluid, causing lymphedema.
Cancer
Tumors from cancer that has metastasized may grow large enough to block lymph vessels, and restrict the flow of lymph fluid, resulting in lymphedema.
Infection
Lymph-node infections, either bacterial or fungal, can restrict the flow of lymph fluid. Infection may also be caused by parasites. Filariasis, which is caused by roundworms, is one such parasitic infection. Infection-related lymphedema is usually found in tropical and subtropical regions, and in developing countries.
Most lymphedema occurs in the arms or legs. Swelling may be barely noticeable or so extreme that using the arm or leg becomes impossible. In many cases, symptoms of lymphedema in the arm and leg include:
Swelling, possibly including fingers or toes
Aching or discomfort
A full or heavy sensation
Restricted range of movement
Tight or shiny skin
Lack of indentation in the skin when pressed
Hardening and thickening of the skin
Small warts or blisters that leak clear fluid
Recurring infections
Tighter-fitting rings and watches
Although most secondary lymphedema appears within three years of cancer surgery and treatment, it may not materialize until many years later.
In some cases, a doctor's exam, which includes measuring the affected limb against the normal one, may be sufficient to diagnose lymphedema. Additional ways to diagnose lymphedema often include:
CT scan
MRI scan
Doppler ultrasound
Radionuclide imaging
There is no cure for primary lymphedema. Treatment for both primary and secondary lymphedema focuses on reducing swelling and controlling pain, and on keeping symptoms from getting worse. Drugs are usually not used to treat lymphedema, unless to fight a resulting infection. Diuretics and blood thinners usually do not help, and may only exacerbate symptoms. Lymphedema treatment often includes:
Compression sleeves or stockings
Exercise that incorporates gentle contraction of muscles in the affected limb
Compression bandages that encourage lymph-fluid drainage to the center of the body
Pneumatic-compression devices
Massage that helps to drain lymph fluid
Several of these treatments may also be combined. To reduce severe swelling, lymphedema may be treated with surgery that removes excess fluid and tissue from the affected limb.
In addition to problems with the functioning of the affected limb, complications from lymphedema often include:
Cellulitis, a bacterial infection of the skin and its tissues
Lymphangitis, an inflammation of the lymphatic vessels
Deep venous thrombosis, blood-clot formation in the deeper veins
Lymphangiosarcoma, cancer of the lymphatic vessels
Lymphangiosarcoma is a rare but aggressive cancer that occurs in those with chronic, long-term lymphedema. A small percentage of women who have had radical mastectomies to treat breast cancer are also affected, often up to ten years after treatment.
There is no way to prevent primary lymphedema, but the risk for getting secondary lymphedema can be reduced by:
Beginning treatment as soon as symptoms occur
Keeping skin and nails clean to prevent infection
Avoiding cuts or wounds to the limb to prevent infection
Keeping fluid from collecting by not crossing the legs or wearing tight clothing
Elevating the limb to keep fluid from collecting
Avoiding heat on the affected limb
Remaining hydrated
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